Infection-Related
Morbidities in the Mother, Fetus and Neonate
Abstract
Only partially
understood host defense mechanisms operate against infections affecting
maternal and fetal morbidity. Subclinical ascending infections through the
lower female genital tract are predominant worldwide. Important micronutrient
deficiencies may prevail in low-income countries where these infections are
much more common than in high-income countries. Important morbidities related
to poor perinatal outcome both for the mother and for the fetus and newborn
comprise preterm birth, prelabor rupture of membranes, placental abruption
(predelivery detachment of the placenta), postpartum sepsis and maternal
anemia. In the fetus, sepsis and intrauterine growth retardation are suspected
to be consequences of ascending maternal infections. In the newborn, septicemia
and respiratory disorders as well as some neurological disorders seem to be
consequences of such ascending genital infections in the pregnant woman. It is
concluded that much more attention should be given to efforts to elucidate the
host defense mechanisms and antimicrobial barriers from the vagina through the
cervix, fetal membranes and amniotic fluid including the early fetal
immunocompetence in the second and the third trimester of pregnancy.
(Fania Anjela)